Leon Goretzka and Robert Lewandowski scored late on to keep Bayern Munich top of the Bundesliga with 4-2 comeback win over Borussia Dortmund in Der Klassiker.
Real Madrid suffered a huge dent to their La Liga title ambitions following a surprise 2-1 defeat by Levante.
Real Madrid suffered a shock 2-1 defeat to third division Alcoyano to exit the Copa del Rey after extra-time on Wednesday night.
Gianluca Mancini's late goal earned hosts Roma a 2-2 draw with Inter which left the visitors three points behind leaders AC Milan in the Serie A title race.
Real Madrid moved top of La Liga after a 2-0 home win over Celta Vigo with Lucas Vazquez and Marco Asensio on the scoresheet.
Lionel Messi equalled Pele's record of 643 goals for a single club after scoring for Barcelona against Valencia in La Liga on Saturday.
A costly mistake from goalkeeper Thibaut Courtois helped Alaves secure a 2-1 La Liga victory over Real Madrid at the Alfredo Di Stefano stadium.
Serie A leaders AC Milan dropped their first points of the season, despite a Zlatan Ibrahimovic double, when defiant Roma came from behind three times to draw 3-3.
Zlatan Ibrahimovic made a winning return to the AC Milan team as his quickfire double won the Milan derby, while Real Madrid and Barcelona suffered shock defeats.
Sergio Ramos' late penalty helped secure Real Madrid a 3-2 victory at Real Betis, who finished the La Liga match with 10 men, plus all the latest from around Europe.
Timo Werner scored twice on his RB Leipzig farewell ahead of his move to Chelsea, while Borussia Dortmund were thrashed on the league's final day.
Robert Lewandowski became the most prolific foreign goalscorer in Bundesliga history as champions Bayern Munich saw off Freiburg.
Atletico Madrid drew 1-1 at Athletic Bilbao on their return to La Liga action, failing to capitalise on slip-ups by their rivals for the Champions League places.
Wolfsburg boosted their hopes of qualifying for next season's Europa League with a 1-0 victory at relegation-threatened Werder Bremen.
Schalke's winless Bundesliga run was extended to 11 games as they were beaten 1-0 by strugglers Werder Bremen on Saturday.
Schalke 04's dreadful run of form continued with defeat at Fortuna Dusseldorf, while Hoffenheim beat Cologne to move seventh.
Schalke slumped to a shock 3-0 loss at home to relegation-threatened Augsburg on Sunday as the pressure mounts on manager David Wagner.
RB Leipzig's Bundesliga title hopes suffered a blow as visitors Freiburg held them to a 1-1 draw as the German top flight returned to action.
Augsburg coach Heiko Herrlich will miss the club's first game when the Bundesliga resumes on Saturday, because he broke quarantine rules.
Barcelona were made to work for their win against third-place Getafe in La Liga on Saturday while PSG were held 4-4 by Amiens in France.