Davy Klaassen scored twice as Ajax Amsterdam trounced SC Cambuur 5-1 to extend their lead at the top of the Eredivisie.
Ajax maintained their three-point advantage over Feyenoord with a 1-1 away draw on Sunday, as PSV Eindhoven jumped into second spot.
Feyenoord lost ground in the Eredivisie title race after a shock 1-0 loss against ADO Den Haag.
Nigel Hasselbaink hit a 92nd-minute equaliser to earn Excelsior a 1-1 draw against PSV Eindhoven on Saturday night.
There were Eredivisie wins for both Ajax and PSV on Saturday, while second-placed Heracles slipped to defeat.
Heracles Almelo moved to the top of the Dutch league with a 2-1 win over champions PSV Eindhoven at the Polman Stadion on Saturday.
Ajax's Anwar El Ghazi scored twice in a 4-0 win over ADO Den Haag that took them clear at the top of the Dutch league on Sunday.
Luuk de Jond rescued a point for champions PSV, while their were wins for Heracles and Roda JC.
Michael de Leeuw rescued a point for Groningen in a 1-1 draw with Twente in the Eredivisie on Wednesday, as NEC beat Excelsior 1-0.
AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
NAC Breda face a relegation play-off, while Manchester United-bound Memphis Depay scored for PSV.
AZ Alkmaar remain in contention to clinch a Europa League berth from the Eredivisie after a 2-0 win at FC Twente.
Feyenoord moved a step closer to qualifying for the Europa League after a 2-2 draw at Willem II Tilburg in the Eredivisie.
Markus Henriksen netted a late winner as AZ strengthened their grip on fourth place with a 2-1 win over Cambuur Leeuwarden.
Cash-strapped Twente Enschede returned to winning ways in the Eredivisie on Saturday with a 2-0 win over PEC Zwolle.
AZ Alkmaar had to overcame blustery conditions to beat Willem II 2-0 to reclaim third place in the Eredivisie on Saturday.
Ricardo Kishna struck twice as Ajax beat Twente 4-2 in the Eredivisie to cut PSV's Eredivisie lead back to 12 points.
A calamitous error by Go Ahead Eagles goalkeeper Mickey van der Hart gave parent club Ajax a 2-1 win.
Stefan Nijland scored in each half as PEC Zwolle moved up to third with a thumping 4-0 win at bottom side Dordrecht.
PSV as they scored twice in the last six minutes to defeat Willem II 2-1 on Saturday and extend their Eredivisie lead.