Red-hot Fiorentina replaced Inter Milan as Serie A leaders by cruising to a 3-0 home victory over Atalanta on Sunday.
Napoli made it three wins out of three for Italian sides in the Europa League on Thursday night with a 2-0 victory at Legia Warsaw.
Fiorentina ended Inter Milan's perfect record in stunning style while AC Milan were beaten and Lazio moved up to fourth.
Juventus could only draw 1-1 at home to Frosinone in Serie A on Wednesday, as leaders Inter Milan beat Hellas Verona 1-0.
A Gonzalo Higuain-inspired Napoli ran riot against Lazio while there were also wins for Inter Milan and Fiorentina.
Mario Balotelli hit the post as AC Milan lost 1-0 to leaders Inter in Serie A on Sunday, while Torino remain unbeaten.
Bayer Leverkusen, CSKA Moscow, BATE and Astana all reached the Champions League group stages on Wednesday night.
Serie A champions Juventus saw their 47-match unbeaten home league record come to an end against Udinese.
Differing fortunes for Rome rivals as Lazio beat Bologna and Roma are held by Verona on Serie A's opening day.
With Gazza set to appear on Soccer AM this weekend, we look back at his most iconic moments.
Keita Balde came off the bench to score the winner as Lazio beat Bayer Leverkusen 1-0 at the Stadio Olimpico in Rome.
New signings Mario Mandzukic and Paulo Dybala scored as Juventus beat Lazio 2-0 to win the Italian Supercoppa in Shanghai.
Lazio coach Stefano Pioli has extended his contract with the Serie A side.
Lazio president Claudio Lotito's home raided by authorities as part of an investigation into allegations of attempted extortion.
Lazio forward Miroslav Klose has not ruled out reversing his decision to retire from international football.
Lazio have ruled out a move for Manchester United forward Robin van Persie, saying he is "outside of their parameters".
From Andrea Pirlo to Esteban Cambiasso, we pick the top 10 Bosman transfers...
Rafael Benitez failed to deliver Champions League football to Napoli as his final act before leaving ended in a 4-2 loss to Lazio.
Rafael Benitez failed to deliver Champions League football to Napoli as his final act before leaving as Lazio won 4-2.
Roma booked their place in the group stage of next season's Champions League with a dramatic 2-1 derby win over Lazio.