Gaston Pereiro was PSV Eindhoven hero as he scored twice in a 2-1 win against previously-unbeaten Eredivisie leaders Ajax.
Watch Dominic Solanke leave his marker red-faced with a moment of magic for Vitesse in the Eredivisie.
There were Eredivisie wins for both Ajax and PSV on Saturday, while second-placed Heracles slipped to defeat.
Ajax returned to the top of the Eredivisie with a 2-0 victory over Excelsior on Sunday.
Wout Weghorst scored the only goal as high-flying Heracles beat ADO Den Haag 1-0 to climb to second in the Eredivisie.
Ajax's Anwar El Ghazi scored twice in a 4-0 win over ADO Den Haag that took them clear at the top of the Dutch league on Sunday.
There were wins for Ajax and Feyenoord in the Eredivisie on Sunday, while FC Twente slipped to defeat.
Ajax started their Eredivisie campaign with victory over AZ Alkmaar, while Willem II and Vitesse played out a 1-1 draw.
We profile four young Chelsea players on loan at Vitesse, three of whom featured against Southampton.
Ronald Koeman admitted "it's never over in football" after Southampton beat Vitesse 3-0 in the Europa League.
Maarten Stekelenburg believes Southampton’s best years are ahead of them having joined the club on a season-long loan from Fulham.
Chelsea have announced the signing of teenager Danilo Pantic from Partizan Belgrade.
Southampton have been drawn to play Dutch side Vitesse in the third qualifying round of the Europa League.
Eredivisie side Vitesse Arnhem have signed Chelsea forward Isaiah Brown on loan for the coming season.
Chelsea starlet Lewis Baker will spend next season on loan at Dutch Eredivisie side Vitesse Arnhem.
Vitesse beat Heerenveen 5-2 as they claimed a Europa League place with a 7-4 aggregate win in the post-season play-offs.
AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
Michiel Kramer netted a late winner in a 1-0 victory over Vitesse which all-but confirmed Den Haag's Eredivisie status.
Champions Ajax delayed PSV's impending Eredivisie title win for another week as they won 2-0 away at Heracles Almelo.
Five-star PSV close in on Dutch title after comprehensive victory at FC Twente, while Heracles grab dramatic late win