Iago Aspas scored twice as Celta Vigo beat Deportivo La Coruna 4-1 in a Galician derby in La Liga on Sunday.
Barcelona begin their Copa del Rey defence against Hercules, while Real face a trip to Leon to take on Cultural y Deportiva Leonesa.
Goals from Antoine Griezmann and Kevin Gameiro helped Atletico Madrid to a 2-0 win at Valencia on Sunday.
Argentine international Gabriel Mercado bundled home the winner as Sevilla moved up to second in La Liga with a 1-0 win over rivals Real Betis.
Antoine Griezmann scored twice as Atletico Madrid won 4-0 at Celta Vigo in La Liga on Saturday, while Sevilla and Villarreal also claimed victories.
Malaga president Sheikh Abdullah Al Thani has hinted Real Madrid midfielder Isco could return to the club.
Jon Driscoll and Terry Gibson return for an in-depth take on all the action and major talking points in La Liga.
Malaga battled back to secure a 2-2 draw away to Espanyol in La Liga on Friday evening, while Deportivo and Betis drew 0-0.
The 21st season of live Spanish football on Sky Sports gets underway this weekend with over 300 games available throughout the campaign.
Transfer sagas, managerial changes, new faces, old problems - Guillem Balague previews the new La Liga season.
Malaga have completed the signing of highly-rated winger Jony Rodriguez from La Liga rivals Sporting Gijon.
Former Tottenham manager Juande Ramos has taken charge of La Liga side Malaga on a three-year deal.
Russian club Rubin Kazan have confirmed they have agreed a deal in principle with former Malaga manager Javier Gracia.
Malaga have announced that head coach Javier Gracia will step down this summer.
What was the best goal scored in La Liga this season? Watch 12 of the top strikes here and vote for your favourite...
Catch up with the action as Barcelona, Real Madrid and Atletico continued their battle for the title in La Liga.
Levante's six-year stay in La Liga is over after their 3-1 defeat at Malaga condemned them to relegation.
Fernando Torres struck as Atletico Madrid moved level with Barcelona at the top of La Liga with a 3-0 win over Granada.
Ref Watch debates another selection of controversial decisions from some of the weekend's games in England and Spain.
Roberto Soldado scored the winner as Villarreal came from behind to beat Eibar 2-1 on Sunday.