Peter O'Mahony captains Munster for their trip to Glasgow Warriors while the Ospreys entertain Edinburgh in Swansea.
Ospreys ran in four tries to earn a 22-5 bonus-point success at 14-man Glasgow and move closer to the top of the Guinness PRO12 table.
Glasgow Warriors have signed Australian winger Ratu Tagive on a one-year deal.
Glasgow Warriors have suffered a double injury blow with Leonardo Sarto ruled out for six months and Richie Vernon for three months.
Will Boyde's braced helped Scarlets make it five consecutive Guinness PRO12 victories with a 27-3 triumph over Glasgow.
Rory Hughes' brace helped push Glasgow Warriors to a comfortable 31-14 victory over Treviso at Scotstoun Stadium.
Glasgow and Edinburgh will hope for a financial injection after Scottish Rugby's member clubs voted to allow external investment.
Gregor Townsend has confirmed Matt Taylor and Dan McFarland will join him when he takes over as Scotland head coach.
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