Defending European champions Italy qualified for Euro 2024 after a goalless draw against Ukraine in Germany.
Ten-player Northern Ireland suffered a home defeat to Group H leaders Slovenia after the visitors earned a scrappy 1-0 win at Windsor Park.
Manager Michael O'Neill admitted Northern Ireland's hopes of reaching Euro 2024 were over after their fourth straight qualifying loss, a 4-2 reverse in Slovenia.
Switzerland inflicted Portugal's first UEFA Nations League defeat to put Spain top of Group A2 on Sunday evening.
Anthony Martial rescued a point for France in Ukraine as their winless run extended to five games, while the Netherlands thrashed Montenegro 4-0.
France were held by Ukraine as the defence of their World Cup title started with a 1-1 draw in Paris, while Tomas Soucek scored a hat-trick for Czech Republic.
Michy Batshuayi scored twice as Belgium came from behind to beat Switzerland 2-1 in a friendly ahead of their crucial Nations League clash against England on Sunday.
Germany, the Netherlands, Croatia and Italy all play international friendlies on Wednesday, while Portugal face Spain, all live on Sky Sports .
Spain's Ansu Fati became the national team's youngest ever goalscorer as the 17-year-old inspired Luis Enrique's side to a resounding 4-0 win over Ukraine.
Brothers Eden and Thorgan Hazard combined to help Group I leaders Belgium beat Russia 4-1 and wrap up top spot in Saint Petersburg.
Team news and previews ahead of Saturday's European Qualifiers, with Wales, Northern Ireland and Scotland live on Sky Sports.
Romelu Lukaku hit his 50th and 51st international goals as Belgium became the first team to qualify for Euro 2020 after they hammered San Marino 9-0.
Team news and previews ahead of Thursday's internationals, featuring Northern Ireland, Scotland, Wales, Netherlands, Belgium and more.
Belgium moved closer to reaching Euro 2020 with a routine 4-0 win in San Marino to move eight points clear of third place in Group I.
Santi Cazorla made his first appearance in over four years and Jesus Navas scored his first international goal in six years as Spain beat Faroe Islands.
It is the penultimate matchday of the Nations League on Monday with the Netherlands looking to top Group A1 while the Republic of Ireland bow out of League B.
Gibraltar's hopes of a fairy tale promotion from their UEFA Nations League group ended as they slumped to a 6-2 home defeat by Armenia on Friday.
Ukraine sealed promotion to League A in the UEFA Nations League after a 1-0 victory over Czech Republic in Kharkiv.
Wales, Netherlands and France are all in UEFA Nations League action on Friday, and you can watch every game live on Sky Sports.
Cyprus captain Jason Demetriou was shown a straight red for a shocking tackle in his side's Nations League draw with Slovenia on Tuesday night.